I farmaci per il diabete portano a una significativa perdita di peso nelle persone con obesità: studia

“I risultati indicano che la tirzepatide potrebbe essere una potenziale opzione terapeutica per le persone che vivono con l'obesità, con i partecipanti che perdono in mezzo 16% e 22.5% del loro peso iniziale”, hanno detto gli autori nello studio.

The drug, tirzepatide, is a novel drug that was recently approved by the Food & Drug Administration to help treat type 2 diabetes through a once-weekly injection. The drug, works on two hormones that help control blood sugar and send fullness signals to the brain, the authors explained in the study. The investigators decided to look at the effect of the diabetes drug on obesity and presented the findings of the phase 3 trial at a symposium at the 82nd Scientific Sessions of the American Diabetes Association® (ADA) in New Orleans, IL.

Obese person measuring his belly.

Obese person measuring his belly. (Credito: iStock)

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The 72-week phase 3 double-blind, randomized, controlled trial, involved over 2500 participants who were considered obese and did not have diabetes.

The team of researchers divided the participants into four groups. Three of the groups were given 5mg, 10mg or 15mg of tirzepatide to be self-administered once a week for 72 settimane, while the fourth group was given a self-administered placebo injection. All four groups were given counseling sessions regarding lifestyle habits and low-calorie meals. They also performed at least 150 minutes of physical activity a week.

The investigators found that 89% of participants, who took the 5 mg dose of the drug and 96% of those who took 10 mg and 15 mg weekly doses of the drug, achieved at least 5% body weight reductions rispetto a 28% of those in the placebo group.

A drug meant to treat cholesterol was found to reduce coronavirus infection by 70% in lab studies, with researchers now calling for additional clinical trials among hospitalized COVID-19 patients.

A drug meant to treat cholesterol was found to reduce coronavirus infection by 70% in lab studies, with researchers now calling for additional clinical trials among hospitalized COVID-19 patients. (iStock)

Secondo il rapporto, participants who took the 5 mg dose of tirzepatide lost an average of 35 libbre, e il 10 mg group achieved an average loss of 49 libbre. The participants who took the 15 mg injection saw an average 52-pound weight loss over the 72-week course of the study. Those in the placebo group achieved a 5 lb. average of weight loss, secondo lo studio.

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Obesity should be treated like any other chronic disease – with effective and safe approaches that target underlying disease mechanisms, and these results underscore that tirzepatide may be doing just that,” lead researcher Ania Jastreboff, MD, PhD, an associate professor Yale University School of Medicine, and director of Weight Management and Obesity Prevention at the Yale Stress Center told one media outlet.

Man during bench press exercise in gym

Man during bench press exercise in gym (iStock)

These results are an important step forward in potentially expanding effective therapeutic options for people with obesity. In particolare, di 9 fuori da 10 individuals with obesity lost weight while taking tirzepatide,” Jastreboff, who is also the co-director of the Yale Center for Weight Management in Connecticut said in the media report.

Secondo il Centri per il controllo e la prevenzione delle malattie, (Centro per la prevenzione e il controllo delle malattie), the prevalence of obesity in the United States was nearly 42% nel 2017 fino a marzo 2020. The CDC stated that obesity related conditions include heart disease, stroke, genere 2 diabetes and some types of cancer.

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