Karl-Anthony Towns scored 32 points and D’Angelo Russell added 16 for the Timberwolves, who shot 23 for 48 from beyond the arc, including 16 makes in the first half.
Denver’s Nikola Jokic had 27 points, 10 rebounds and 11 assists for his sixth triple-double of the season and the 63rd of his career.
The Nuggets lost Markus Howard to a lower left leg injury with 9:23 remaining. His leg got tangled in a pile as several players scrambled for a loose ball. He limped off the court, leaning on a pair of team trainers.
The Nuggets pulled to 88-76 on a layup by Jokic midway through the third quarter, but the Timberwolves responded with a 13-2 run that included a pair of 3-pointers by Edwards and another by Towns as they surged in front by 23 points.
The last of Towns’ three 3-pointers allowed him to join Kevin Garnett as the only players in Timberwolves’ history with 10,000 career points.
“I’m humbled,” he said. “It takes a village, it takes a lot of sacrifice, not just from me but from my support system to help me reach this milestone, but I wouldn’t say it’s the goal because it’s not where I want to be at the end. I don’t want this to be the lasting memory of me. I feel like I’ve got a lot more to do in a ’Wolves jersey and I’m just excited to do this with this group of guys in the locker room.”
Minnesota took a 108-88 lead into the final period and maintained a double-digit advantage the rest of the way for their first win against the Nuggets since the final regular-season game of the 2017-18 season.
“I don’t really buy in too much into what happened before,” Minnesota coach Chris Finch said. “I just try to get us as ready to play as possible. I don’t think the guys really sensed anything that we haven’t beaten these guys in 12 attempts. Players are unique that way — they always think they’re going to win the next game.”
Cashing in from the perimeter, the Timberwolves led by as many as 20 points in the first half and took a 75-61 lead into the intermission. They put up the most first-half points by a Nuggets opponent this season, converting 16 of their first 29 shots from beyond the arc.
Edwards hit five of his 3-pointers in the first half, and Patrick Beverley and Russell each had three in the first two quarters.
“They made all those 3s, Edwards was the biggest, scoring 10 of them,” Jokic said. “But it wasn’t just him We, as a group, need to be better (defensively) and hopefully we will.”
Timberwolves: The 16 made 3-pointers in the first half were the most by any NBA team this season. … Edwards’ 10 3s were the most in a game in Timberwolves history.
Nuggets: The Spurs had 74 first-half points against the Nuggets a week ago. … Will Barton returned to action after missing the two previous games with a non-COVID illness. … G Austin Rivers missed an eighth game due to the league’s health and safety protocols. … F JaMychal Green missed a second consecutive game with a right ankle sprain.
Timberwolves: Host the Los Angeles Lakers on Friday night.
Nuggets: Open three-game road at Atlanta on Friday night.