The team said Tuesday that Etienne, a first-round draft pick from Clemson, has a Lisfranc injury. He was placed on injured reserve and is expected to have surgery as soon as possible.
Since Etienne was placed on IR before the final 53-man roster deadline next Tuesday, his season is over.
Losing Etienne is a significant setback for the Jaguars, who planned to use him to create mismatches in the slot and as a third-down back.
Jacksonville selected Etienne with the 25th overall pick in April’s draft and paired him with fellow Clemson star Trevor Lawrence.
Etienne is the Atlantic Coast Conference’s career leading rusher, tallying 4,952 yards in four seasons. He also set league records for rushing touchdowns (70), total touchdowns (78) and total points scored (468). He scored at least one touchdown in 46 of 55 career games.
Etienne had been part of a three-back attack for Jacksonville, sharing carries with starter James Robinson and backup Carlos Hyde. But Etienne has more speed and elusiveness than either one and was expected to play a major role in coach Urban Meyer’s offense.