Mark Canha had two hits and two RBIs for Oakland, and Jed Lowrie finished with three hits. The AL West leaders won for the sixth time in seven games.
The Diamondbacks dropped their seventh straight game overall. Their road slide is the longest such streak in major league baseball since 1985.
Manaea (5-2) extended his scoreless streak to 15 innings. He struck out three and walked two in his second straight win.