The Cardinals (6-0) built a 20-0 lead in the first half and kept their perfect record intact despite not having Kingsbury or star linebacker Chandler Jones, who both tested positive for COVID-19 this week.
Murray connected with DeAndre Hopkins for two TDs, and Arizona’s shifty quarterback came up with a clutch play whenever the Cardinals needed one.
The Browns (3-3) have lost two straight under coach Kevin Stefanski for the first time and Cleveland has bigger concerns, most notably to a growing list of major injuries. The latest was to running back Kareem Hunt, carted to the locker room in the fourth quarter with a calf injury.
Cleveland was already missing star running back Nick Chubb (calf) and the Browns, who host Denver on Thursday night, played without both their starting offensive tackles.
Also, quarterback Baker Mayfield appeared to reinjure his left shoulder and wide receiver Odell Beckham Jr. briefly left with a shoulder issue. Mayfield committed three turnovers: two fumbles and an interception.
The Browns were trailing 23-14 when Cardinals star defensive end J.J. Watt chased down Mayfield and forced a fumble by sweeping out the QB’s legs. Mayfield stayed down for several minutes — with Watt kneeling nearby — and was twice examined in the medical tent, but stayed in.
After his fumble, Murray made the Browns pay by throwing a 9-yard pass to a wide-open Hopkins to put the Cardinals ahead 30-14.
Later, Hunt was not targeted on a pass play and the bruising back crumpled to the ground without contact. He was unable to put any weight on his leg while being assisted to the sideline.
Arizona learned Friday it would be without Kingsbury, the team’s play caller, along with quarterbacks coach Cam Turner and defensive linemen Zach Allen after positive COVID-19 tests. They were already going to be missing Jones and then defensive linemen Corey Peters was placed on the COVID-19 reserve list before the game.
Murray made sure the Cardinals didn’t miss a beat. He completed 20 of 30 passes for 229 yards and matched his career best with the four TDs.
Desperate for a positive play, the Browns got one on the final snap of the first half as Mayfield completed a 57-yard TD pass to Donovan Peoples-Jones.
A week ago, Mayfield attempted a similar “Hail Mary” on the last play in a 47-42 loss to the Chargers.
Cleveland’s defense helped the Cardinals by committing four penalties for 43 yards on Arizona’s second scoring drive. Two of the calls went against tackle Malik McDowell, for face masking and roughing on Murray.
On third-and-goal, Murray hit Hopkins with a short pass and he eluded two tacklers for a 13-yard TD to make it 14-0.
LANDRY ON DECK
Browns wide receiver Jarvis Landry could return Thursday. The five-time Pro Bowler missed his fourth game with a sprained medial collateral ligament.
Landry was designated for return from injured reserve Friday, clearing the way for him to be activated. Before getting hurt on Sept. 19 and then missing the next game, Landry had never missed a game due to injury in his eight-year career.
Cardinals: DL Rashard Lawrence (calf) didn’t play in the second half. … TE Darrell Daniels suffered a hamstring injury in the first half and didn’t return.
Browns: Rookie LB Jeremiah Owusu-Koramoah went to the locker room in the fourth period with an unspecified injury.
Cardinals: host the Houston Texans on Oct. 24. It’s the first of three home games in four weeks for Arizona.
Browns: little time to heal with the Broncos coming in for the second of Cleveland’s three home games in two weeks.