神秘的儿童肝炎爆发: 英国研究可能确定主要嫌疑人

“截至5月 5, 2022, CDC and state partners are 调查中 109 儿童不明原因肝炎 25 州和领地, 其中一半以上的人腺病毒检测呈阳性,超过 90% 住院, 14% with liver transplants, and five deaths under investigation,” the CDC said.

大约 18% of cases worldwide actively also tested positive for COVID-19, according to a Medical Xpress report.

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The big focus over the next week is looking at serological testing for previous exposure and infections with COVID,” Philippa Easterbrook, from the WHO’s global hepatitis program, told a press 会议.

Easterbrook said within the week the United Kingdom will have data on a case control study comparing whether the detection rate of adenovirus in the children who have hepatitis differs from that in other hospitalized children who don’t have the liver disease.

That will really help hone down whether [adenovirus] is just an incidental infection that’s been detected or there is a causal or likely causal link,” Easterbrook 说过.

At present, the leading hypotheses remain those which involve adenovirus — with also still an important consideration about the role of COVID as well, either as a co-infection or a past 感染.”

A fundamental question is whether there is a characteristic pattern in the pathology of the liver in these patients. Such a pattern might be seen at the advanced stage when liver transplantation was performed, or earlier before the severe liver damage of the unknown process had perhaps obscured an earlier characteristic pattern,” 博士说. Daniel Lucey, clinical professor of medicine at Dartmouth Geisel School of Medicine.

If such a liver pathology pattern has been found, then it could be used to help identify the etiology of the hepatitis or at least serve to provide a unifying clinical-pathologic syndrome as soon as possible.

None of the U.K. liver samples… show any of the typical features you might expect with a liver inflammation due to adenovirus but we are awaiting further examination of biopsies,” Easterbrook 添加.

LAS VEGAS, NEVADA - 可能 14:  (左) Illusionist Criss Angel, his son Johnny Crisstopher Sarantakos and Shaunyl Benson visit as Angel helps to give out food and other items at the Cure 4 The Kids Foundation pediatric cancer treatment center amid the spread of the coronavirus on May 14, 2020, 在拉斯维加斯, 内华达州.

LAS VEGAS, NEVADA – 可能 14: (左) Illusionist Criss Angel, his son Johnny Crisstopher Sarantakos and Shaunyl Benson visit as Angel helps to give out food and other items at the Cure 4 The Kids Foundation pediatric cancer treatment center amid the spread of the coronavirus on May 14, 2020, 在拉斯维加斯, 内华达州. (图片由伊桑·米勒/盖蒂图片社)

Because adenoviruses are used in some of the COVID-19 vaccinations, one theory on social media suggested a link between the jab and the hepatitis outbreak in the U.K., where most of the cases have been reported, 根据 路透社.

But these adenoviruses in the vaccines areharmless transporters which have been modified so they cannot replicate or cause infection,” according to BBC 新闻.

There is no evidence of any link to the coronavirus (新冠肺炎) 疫苗. The majority of cases are under 5 岁, and are too young to have received the vaccine,” the U.K. Health Security Agency (UKHSA) 说过.

The United Kingdom International Health Regulations National Focal Point first reported 10 cases of severe hepatitis of unknown etiology on April 5, 2022, in children ranging from 11 months to 5 years old in Scotland, WHO 说过.

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“在5月 11, the European CDC 已报告 总共 449 probable 案件 27 nations including from Europe, the Americas (北, Central and South), Asia and the Middle East,” Lucey 说过.

The highest numbers of cases so far are: 英国. (163), 美国 (109), 意大利 (35), 西班牙 (22), 巴西 (16), 印度尼西亚 (15), 以色列 (12), 瑞典 (九), 阿根廷 (八), 日本 (七) and Canada (七).”

More than five cases have only been reported in six countries. The United Kingdom have reported the most cases in the world, but no child has died so far in the country, according to a May 12 UKHSA 声明.

Hepatitis, otherwise known as liver inflammation, is commonly caused by viruses, medications or exposure to certain chemicals, 根据 Healthline.

Most of the children in the reported cases presented with gastrointestinal symptoms such as vomiting, diarrhea, 和 abdominal pain,” 博士说. Norberto Rodriguez-Baez, a professor of pediatrics at the University of Texas Southwestern Medical 中央.

These symptoms were followed by development of jaundice,” 他 添加.

Jaundice is when the skin and eyes turn yellow because the liver loses its ability to clear bilirubin properly, per Healthline.

Interestingly, fever was not described as a common symptom in these cases. 此外, all children were previously 健康,” Rodriguez-Baez said.

It’s important that parents know the likelihood of their child developing hepatitis is extremely low. We continue to remind everyone to be alert to the signs of hepatitis – particularly jaundice, look for a yellow tinge in the whites of the eyes – and contact your doctor if you are concerned,” 博士说. Meera Chand, director of clinical and emerging infections at UKHSA.

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