McCaffrey already has missed two games, both Carolina losses.
The earliest he will be able to return to game action is Nov. 7 against the New England Patriots. McCaffrey will have missed 18 of 24 games with injuries since becoming the league’s highest-paid running back following the 2019 season.
The Panthers (3-2) host the Minnesota Vikings (2-3) on Sunday. Chuba Hubbard will continue to start for McCaffrey.
McCaffrey practiced on Wednesday on a limited basis but was held out on Thursday and Friday.